Prof Janardhan Reddy

Clinical Co-ordinator & Co-Principal Investigator

Designation: Professor, Department of Psychiatry & Head of Obsessive-Compulsive Disorder (OCD) Clinic

Areas of Research:

Obsessive Compulsive Disorder, Bipolar Disorder, Long-term Outcomes

Description/CV:

Dr Reddy is a Professor of Psychiatry at the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India. He completed his MBBS from the Government Medical College, Bellary in 1986 and obtained his MD degree in psychiatry from the NIMHANS in 1991. He is on the faculty of the department of Psychiatry at NIMHANS since 1995. The obsessive-compulsive disorder (OCD) clinic at the institute is headed by him. The OCD clinic is involved in clinical services, post-graduate training and research. His areas of specialization include obsessive-compulsive and related disorders, bipolar disorders and clinical psychopharmacology. Dr Reddy has special interest in studying the long-term course and outcome of OCD and bipolar disorders and in the management of treatment resistant OCD patients. Recently, the OCD Clinic has initiated neurosurgery program for treatment refractory OCD patients. Dr Reddy is involved in studies of phenomenology, comorbidty, family-genetics, treatment resistance, neuropsychology and neuroimaging in OCD. His current area of study involves studying neuropsychological and neuroimaging endophenotypes in OCD. He has published extensively in international and national peer reviewed journals on OCD and bipolar disorders. He is also the reviewer for many national and international journals in psychiatry. In view of his interest in clinical psychopharmacology, Dr Reddy has participated in international clinical drug trials of schizophrenia, bipolar disorder and OCD. He mentors post-graduate and doctoral students in their research work and is a mentor of the Fogarty Indo-US Training Program. He was awarded the Visiting commonwealth research fellow at the Oxford University Department of Psychiatry, Warneford Hospital, Oxford, UK in the years 1999 and 2000. He has also been awarded the prestigious Sir C.V. Raman State Award for the Young Scientists for the year 2011 by the Government of Karnataka. Dr. Reddy has funded projects on OCD from the Department of Biotechnology (DBT), the Department of Science and Technology (DST) and the Indian Council of Medical Research (ICMR) of the Government of India. He is a member of the WHO Working Group on Obsessive-Compulsive and Related Disorders for revision of ICD-10.

Links:

Google Scholar

Research Gate

NIMHANS Website

Selected Publications:

Ganesh, S., Ahmed P, H., Nadella, R. K., More, R. P., Seshadri, M., Viswanath, B., Rao, M., Jain, S., ADBS Consortium, & Mukherjee, O. (2019). Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes. Psychiatry and Clinical Neurosciences, 73(1), 11–19. https://doi.org/10.1111/pcn.12788
Brakoulias, V., Starcevic, V., Albert, U., Arumugham, S. S., Bailey, B. E., Belloch, A., Borda, T., Dell’Osso, L., Elias, J. A., Falkenstein, M. J., Ferrao, Y. A., Fontenelle, L. F., Jelinek, L., Kalogeraki, L., Kay, B., Laurito, L. D., Lochner, C., Maina, G., Marazziti, D., … Fineberg, N. A. (2019). Treatments used for obsessive-compulsive disorder-An international perspective. Human Psychopharmacology, 34(1), e2686. https://doi.org/10.1002/hup.2686
Narayanaswamy, J. C., Jose, D., Agarwal, S. M., Kalmady, S. V., Baruah, U., Shivakumar, V., Prasad, C., Viswanath, B., Rao, N. P., Venkatasubramanian, G., & Janardhan Reddy, Y. C. (2019). Neuro-hemodynamic endophenotypes of emotional interference in OCD: fMRI study using emotion counting stroop task. Asian Journal of Psychiatry, 39, 35–41. https://doi.org/10.1016/j.ajp.2018.11.015
Viswanath, B., Mj, R. J. T., Nadella, R. K., Shukla, T., Nanjundaswamy, M. H., Purushottam, M., Janardhan Reddy, Y. C., & Jain, R. S. (2018). Does GRIN2B gene influence obsessive-compulsive disorder risk, symptom dimensions and treatment response? Asian Journal of Psychiatry, 31, 150–151. https://doi.org/10.1016/j.ajp.2017.12.013
Nawani, H., Narayanaswamy, J. C., Basavaraju, S., Bose, A., Mahavir Agarwal, S., Venkatasubramanian, G., & Janardhan Reddy, Y. C. (2018). Enhanced error related negativity amplitude in medication-naïve, comorbidity-free obsessive compulsive disorder. Psychiatry Research, 262, 373–377. https://doi.org/10.1016/j.psychres.2017.09.010
Viswanath, B., Rao, N. P., Narayanaswamy, J. C., Sivakumar, P. T., Kandasamy, A., Kesavan, M., Mehta, U. M., Venkatasubramanian, G., John, J. P., Mukherjee, O., Purushottam, M., Kannan, R., Mehta, B., Kandavel, T., Binukumar, B., Saini, J., Jayarajan, D., Shyamsundar, A., Moirangthem, S., … Jain, S. (2018). Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry, 18(1), 106. https://doi.org/10.1186/s12888-018-1674-2
Guadalupe, T., Mathias, S. R., vanErp, T. G. M., Whelan, C. D., Zwiers, M. P., Abe, Y., Abramovic, L., Agartz, I., Andreassen, O. A., Arias-Vásquez, A., Aribisala, B. S., Armstrong, N. J., Arolt, V., Artiges, E., Ayesa-Arriola, R., Baboyan, V. G., Banaschewski, T., Barker, G., Bastin, M. E., … Francks, C. (2017). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior, 11(5), 1497–1514. https://doi.org/10.1007/s11682-016-9629-z
Sreedhar, D., Kulkarni, K. R., Purty, A., Muralidharan, K., Janardhan Reddy, Y. C., & Jain, S. (2017). Gender Differences in the 5 Years Course of Bipolar Disorder after a First Manic Episode: A Retrospective Review. Indian Journal of Psychological Medicine, 39(5), 712–713. https://doi.org/10.4103/0253-7176.217020
Jaisoorya, T. S., Janardhan Reddy, Y. C., Nair, B. S., Rani, A., Menon, P. G., Revamma, M., Jeevan, C. R., Radhakrishnan, K. S., Jose, V., & Thennarasu, K. (2017). Prevalence and correlates of obsessive-compulsive disorder and subthreshold obsessive-compulsive disorder among college students in Kerala, India. Indian Journal of Psychiatry, 59(1), 56–62. https://doi.org/10.4103/0019-5545.204438
Janardhan Reddy, Y. C., Sundar, A. S., Narayanaswamy, J. C., & Math, S. B. (2017). Clinical practice guidelines for Obsessive-Compulsive Disorder. Indian Journal of Psychiatry, 59(Suppl 1), S74–S90. https://doi.org/10.4103/0019-5545.196976
Kumar, A., Sharma, M. P., Narayanaswamy, J. C., Kandavel, T., & Janardhan Reddy, Y. C. (2016). Efficacy of mindfulness-integrated cognitive behavior therapy in patients with predominant obsessions. Indian Journal of Psychiatry, 58(4), 366–371. https://doi.org/10.4103/0019-5545.196723
Narayanaswamy, J. C., Jose, D., Kalmady, S. V., Agarwal, S. M., Venkatasubramanian, G., & Janardhan Reddy, Y. C. (2016). Cerebellar volume deficits in medication-naïve obsessive compulsive disorder. Psychiatry Research. Neuroimaging, 254, 164–168. https://doi.org/10.1016/j.pscychresns.2016.07.005
Hegde, A., Ravi, M., V S, S., Arumugham, S. S., Thirthalli, J., & Janardhan Reddy, Y. C. (2016). Repetitive Transcranial Magnetic Stimulation Over Presupplementary Motor Area May Not Be Helpful in Treatment-Refractory Obsessive-Compulsive Disorder: A Case Series. The Journal of ECT, 32(2), 139–142. https://doi.org/10.1097/YCT.0000000000000291
Jaisoorya, T. S., Janardhan Reddy, Y. C., Thennarasu, K., Beena, K. V., Beena, M., & Jose, D. C. (2015). An epidemological study of obsessive compulsive disorder in adolescents from India. Comprehensive Psychiatry, 61, 106–114. https://doi.org/10.1016/j.comppsych.2015.05.003
Shashidhara, M., Sushma, B. R., Viswanath, B., Math, S. B., & Janardhan Reddy, Y. C. (2015). Comorbid obsessive compulsive disorder in patients with bipolar-I disorder. Journal of Affective Disorders, 174, 367–371. https://doi.org/10.1016/j.jad.2014.12.019
Devi, S., Rao, N. P., Badamath, S., Chandrashekhar, C. R., & Janardhan Reddy, Y. C. (2015). Prevalence and clinical correlates of obsessive-compulsive disorder in schizophrenia. Comprehensive Psychiatry, 56, 141–148. https://doi.org/10.1016/j.comppsych.2014.09.015
Jayarajan, R. N., Agarwal, S. M., Viswanath, B., Kalmady, S. V., Venkatasubramanian, G., Srinath, S., Chandrashekar, C. R., & Janardhan Reddy, Y. C. (2015). A Voxel Based Morphometry Study of Brain Gray Matter Volumes in Juvenile Obsessive Compulsive Disorder. Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal De l’Academie Canadienne De Psychiatrie De L’enfant Et De L’adolescent, 24(2), 84–91.
Grant, J. E., Atmaca, M., Fineberg, N. A., Fontenelle, L. F., Matsunaga, H., Janardhan Reddy, Y. C., Simpson, H. B., Thomsen, P. H., van den Heuvel, O. A., Veale, D., Woods, D. W., & Stein, D. J. (2014). Impulse control disorders and “behavioural addictions” in the ICD-11. World Psychiatry: Official Journal of the World Psychiatric Association (WPA), 13(2), 125–127. https://doi.org/10.1002/wps.20115
Cherian, A. V., Narayanaswamy, J. C., Viswanath, B., Guru, N., George, C. M., Bada Math, S., Kandavel, T., & Janardhan Reddy, Y. C. (2014). Gender differences in obsessive-compulsive disorder: findings from a large Indian sample. Asian Journal of Psychiatry, 9, 17–21. https://doi.org/10.1016/j.ajp.2013.12.012
Amar, B. R., Yadav, R., Janardhan Reddy, Y. C., & Pal, P. K. (2014). A clinical profile of patients with Parkinson’s disease and psychosis. Annals of Indian Academy of Neurology, 17(2), 187–192. https://doi.org/10.4103/0972-2327.132625
Narayanaswamy, J. C., Kalmady, S. V., Cherian, A. V., Venkatasubramanian, G., & Reddy, J. Y. C. (2014). Neuroanatomical correlates of naturalistic long-term outcome of obsessive-compulsive disorder treated with selective serotonin reuptake inhibitors. Journal of Clinical Psychopharmacology, 34(2), 282–285. https://doi.org/10.1097/JCP.0000000000000101
Cherian, A. V., Pandian, D., Bada Math, S., Kandavel, T., & Janardhan Reddy, Y. C. (2014). Family accommodation of obsessional symptoms and naturalistic outcome of obsessive-compulsive disorder. Psychiatry Research, 215(2), 372–378. https://doi.org/10.1016/j.psychres.2013.11.017
Roopesh, B. N., Janardhan Reddy, Y. C., & Mukundan, C. R. (2013). Neuropsychological deficits in drug naïve, non-depressed obsessive-compulsive disorder patients. Asian Journal of Psychiatry, 6(2), 162–170. https://doi.org/10.1016/j.ajp.2012.10.003
Taj M J, R. J., Viswanath, B., Purushottam, M., Kandavel, T., Janardhan Reddy, Y. C., & Jain, S. (2013). DRD4 gene and obsessive compulsive disorder: do symptom dimensions have specific genetic correlates? Progress in Neuro-Psychopharmacology & Biological Psychiatry, 41, 18–23. https://doi.org/10.1016/j.pnpbp.2012.10.023
Arumugham, S. S., & Reddy, J. Y. C. (2013). Augmentation strategies in obsessive-compulsive disorder. Expert Review of Neurotherapeutics, 13(2), 187–202; quiz 203. https://doi.org/10.1586/ern.12.160
Rao, N. P., Reddy, M. S., & Reddy, J. Y. C. (2013). Is there a Role for Immunological Mechanisms in Etiopathogenesis of Obsessive Compulsive Disorder? Indian Journal of Psychological Medicine, 35(1), 1–3. https://doi.org/10.4103/0253-7176.112192
Narayanaswamy, J. C., Viswanath, B., Veshnal Cherian, A., Bada Math, S., Kandavel, T., & Janardhan Reddy, Y. C. (2012). Impact of age of onset of illness on clinical phenotype in OCD. Psychiatry Research, 200(2–3), 554–559. https://doi.org/10.1016/j.psychres.2012.03.037
Venkatasubramanian, G., Zutshi, A., Jindal, S., Srikanth, S. G., Kovoor, J. M. E., Kumar, J. K., & Janardhan Reddy, Y. C. (2012). Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: a surface-based morphometry study. Journal of Psychiatric Research, 46(9), 1161–1168. https://doi.org/10.1016/j.jpsychires.2012.06.003
Jayarajan, R. N., Venkatasubramanian, G., Viswanath, B., Janardhan Reddy, Y. C., Srinath, S., Vasudev, M. K., & Chandrashekar, C. R. (2012). White matter abnormalities in children and adolescents with obsessive-compulsive disorder: a diffusion tensor imaging study. Depression and Anxiety, 29(9), 780–788. https://doi.org/10.1002/da.21890
Janardhan Reddy, Y. C. (2012). Prodromal symptoms of recurrences of mood episodes in bipolar disorder. The Indian Journal of Medical Research, 135, 154–156.
Anand, N., Sudhir, P. M., Math, S. B., Thennarasu, K., & Janardhan Reddy, Y. C. (2011). Cognitive behavior therapy in medication non-responders with obsessive-compulsive disorder: a prospective 1-year follow-up study. Journal of Anxiety Disorders, 25(7), 939–945. https://doi.org/10.1016/j.janxdis.2011.05.007
Mahasuar, R., Janardhan Reddy, Y. C., & Math, S. B. (2011). Obsessive-compulsive disorder with and without bipolar disorder. Psychiatry and Clinical Neurosciences, 65(5), 423–433. https://doi.org/10.1111/j.1440-1819.2011.02247.x
Kulkarni, S., Jain, S., Janardhan Reddy, Y. C., Kumar, K. J., & Kandavel, T. (2010). Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder. Bipolar Disorders, 12(6), 647–656. https://doi.org/10.1111/j.1399-5618.2010.00857.x
Viswanath, B., Janardhan Reddy, Y. C., Kumar, K. J., Kandavel, T., & Chandrashekar, C. R. (2009). Cognitive endophenotypes in OCD: a study of unaffected siblings of probands with familial OCD. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(4), 610–615. https://doi.org/10.1016/j.pnpbp.2009.02.018
Math, S. B., Thoduguli, J., Janardhan Reddy, Y. C., Manoj, P. N., Zutshi, A., Rajkumar, R. P., & Adarsh, A. M. (2007). A 5-year course of predominantly obsessive vs. mixed subtypes of obsessive-compulsive disorder. Indian Journal of Psychiatry, 49(4), 250–255. https://doi.org/10.4103/0019-5545.37664
Math, S. B., & Janardhan Reddy, Y. C. (2007). Issues in the pharmacological treatment of obsessive-compulsive disorder. International Journal of Clinical Practice, 61(7), 1188–1197. https://doi.org/10.1111/j.1742-1241.2007.01356.x
Bhattacharyya, S., Prasanna, C. L. N., Khanna, S., Janardhan Reddy, Y. C., & Sheshadri, S. (2005). A family genetic study of clinical subtypes of obsessive-compulsive disorder. Psychiatric Genetics, 15(3), 175–180.
Harbishettar, V., Pal, P. K., Janardhan Reddy, Y. C., & Thennarasu, K. (2005). Is there a relationship between Parkinson’s disease and obsessive-compulsive disorder? Parkinsonism & Related Disorders, 11(2), 85–88. https://doi.org/10.1016/j.parkreldis.2004.07.006
Ravi Kishore, V., Samar, R., Janardhan Reddy, Y. C., Chandrasekhar, C. R., & Thennarasu, K. (2004). Clinical characteristics and treatment response in poor and good insight obsessive-compulsive disorder. European Psychiatry: The Journal of the Association of European Psychiatrists, 19(4), 202–208. https://doi.org/10.1016/j.eurpsy.2003.12.005
Jaisoorya, T. S., Janardhan Reddy, Y. C., & Srinath, S. (2003). Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder?–Findings from an Indian study. European Child & Adolescent Psychiatry, 12(6), 290–297. https://doi.org/10.1007/s00787-003-0342-2
Somnath, C. P., Janardhan Reddy, Y. C., & Jain, S. (2002). Is there a familial overlap between schizophrenia and bipolar disorder? Journal of Affective Disorders, 72(3), 243–247.
Srinath, S., Janardhan Reddy, Y. C., Girimaji, S. R., Seshadri, S. P., & Subbakrishna, D. K. (1998). A prospective study of bipolar disorder in children and adolescents from India. Acta Psychiatrica Scandinavica, 98(6), 437–442.