ADBS Coordinator & Principal Investigator


Designation: Professor, Department of Psychiatry, NIMHANS

Areas of Research:

Genetics of Psychiatric Disorders, History of Psychiatry, Phenomenology, Biological Psychiatry

Biosketch:

Sanjeev Jain is a clinician and a teacher, and researches the genetic correlates of psychiatric and neurological disease. He studied medicine at the Delhi University (Maulana Azad Medical College); and did his post-graduate studies at the NIMHANS. He has been a Commonwealth Fellow at Cambridge (UK), and the co-Director of a NIH-Fogarty training and mentorship program. He has provided the lead for, and participated in, several population and cohort studies, and also provides genetic testing for several neuro-degenerative disorders, as well as counseling services for these families. This work includes the genetics of schizophrenia, bipolar disorder, Alzheimer’s disease and Huntington’s disease, as well as addiction and OCD. Over the past few years, discussions and collaboration with other colleagues at NIMHANS, the NCBS and inSTEM, have extended the research from the clinic, to the bench, using both clinical assessments (including MRI, EEG etc.) as well as tools of cellular and molecular biology, including WES,  iPSC and neuronal cell lines from individuals diagnosed to have psychiatric illnesses, and their affected and unaffected relatives. He has been a member of the committee for drafting the Mental Health Policy document for India; and is also an Adjunct Faculty at the National Centre for Biological Sciences (TIFR), Bangalore. His other interests include the history of mental health services in India, from the colonial to the contemporary period. This work has helped understand the interface between science and medicine, and social responses to mental illness in India. The work has been supported by various funding agencies in India (DBT, ICMR, DST and the CSIR), as also the Wellcome Trust, NIH (Fogarty) and the MRC-ICMR.

Links:

Selected Publications

Sreeraj, V. S., Holla, B., Ithal, D., Nadella, R. K., Mahadevan, J., Balachander, S., … Viswanath, B. (2020). Psychiatric symptoms and syndromes transcending diagnostic boundaries in multiplex families (preprint). Psychiatry and Clinical Psychology. https://doi.org/10.1101/2020.01.06.20016543
Timothy, A., Benegal, V., Shankarappa, B., Saxena, S., Jain, S., & Purushottam, M. (2019). Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 94, 109649. https://doi.org/10.1016/j.pnpbp.2019.109649
Someshwar, A., Holla, B., Agarwal, P. P., Thomas, A., Jose, A., Joseph, B., … Viswanath, B. (2019). Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses (preprint). Neuroscience. https://doi.org/10.1101/745521
Anjanappa, R. M., Jain, S., Wali, G. M., & Purushottam, M. (2019). Genetic analysis of a family from India with Machado-Joseph disease. Neurology India, 67(2), 582–588. https://doi.org/10.4103/0028-3886.258030
Ganesh, S., Ahmed P, H., Nadella, R. K., More, R. P., Seshadri, M., Viswanath, B., … Mukherjee, O. (2019). Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes. Psychiatry and Clinical Neurosciences, 73(1), 11–19. https://doi.org/10.1111/pcn.12788
Ashok, A., Naaz, S., Kota, L. N., Sen, S., Purushottam, M., Faruq, M., … Viswanath, B. (2019). Does retinoic acid reverse cell cycle dysregulation in Alzheimer’s disease lymphocytes? Asian Journal of Psychiatry, 39, 174–177. https://doi.org/10.1016/j.ajp.2018.08.010
Nadella, R. K., Chellappa, A., Subramaniam, A. G., More, R. P., Shetty, S., Prakash, S., … Kannan, R. (2019). Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance. Human Genomics, 13(1), 53. https://doi.org/10.1186/s40246-019-0236-0
Najar, A. H., Sneha, K. M., Ashok, A., Babu, S., Subramaniam, A. G., Kannan, R., … Jain, S. (2019). Derivation of iPSC lines from two patients with familial Alzheimer’s disease from India. Stem Cell Research, 34, 101370. https://doi.org/10.1016/j.scr.2018.101370
Taj M J, R. J., Ganesh, S., Shukla, T., Deolankar, S., Nadella, R. K., Sen, S., … Viswanath, B. (2018). BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response. Asian Journal of Psychiatry, 38, 65–69. https://doi.org/10.1016/j.ajp.2017.10.014
Venkatesh, S. D., Kandasamy, M., Moily, N. S., Vaidyanathan, R., Kota, L. N., Adhikarla, S., … Purushottam, M. (2018). Genetic testing for clinically suspected spinocerebellar ataxias: report from a tertiary referral centre in India. Journal of Genetics, 97(1), 219–224.
Viswanath, B., Mj, R. J. T., Nadella, R. K., Shukla, T., Nanjundaswamy, M. H., Purushottam, M., … Jain, R. S. (2018). Does GRIN2B gene influence obsessive-compulsive disorder risk, symptom dimensions and treatment response? Asian Journal of Psychiatry, 31, 150–151. https://doi.org/10.1016/j.ajp.2017.12.013
Sathur Raghuraman, B., Paul, P., Nadella, R. K., Kapur, V., Purushottam, M., Jain, S., … Viswanath, B. (2018). GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response. Journal of Affective Disorders, 241, 433–435. https://doi.org/10.1016/j.jad.2018.08.079
Stezin, A., Venkatesh, S. D., Thennarasu, K., Purushottam, M., Jain, S., Yadav, R., & Pal, P. K. (2018). Non-ataxic manifestations of Spinocerebellar ataxia-2, their determinants and predictors. Journal of the Neurological Sciences, 394, 14–18. https://doi.org/10.1016/j.jns.2018.08.024
Syama, A., Sen, S., Kota, L. N., Viswanath, B., Purushottam, M., Varghese, M., … Mukherjee, O. (2018). Mutation burden profile in familial Alzheimer’s disease cases from India. Neurobiology of Aging, 64, 158.e7-158.e13. https://doi.org/10.1016/j.neurobiolaging.2017.12.002
Viswanath, B., Rao, N. P., Narayanaswamy, J. C., Sivakumar, P. T., Kandasamy, A., Kesavan, M., … Jain, S. (2018). Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry, 18(1), 106. https://doi.org/10.1186/s12888-018-1674-2
Shankarappa, B. M., Kota, L. N., Purushottam, M., Nagpal, K., Mukherjee, O., Viswanath, B., … Jain, S. (2017). Effect of CLU and PICALM polymorphisms on AD risk: A study from south India. Asian Journal of Psychiatry, 27, 7–11. https://doi.org/10.1016/j.ajp.2016.12.017
Thippeswamy, H., Paul, P., Purushottam, M., Philip, M., Jain, S., & Chandra, P. S. (2017). Estrogen pathway related genes and their association with risk of postpartum psychosis: A case control study. Asian Journal of Psychiatry, 26, 82–85. https://doi.org/10.1016/j.ajp.2017.01.014
Paul, P., Dahale, A., Kishore, B., Chand, P., Benegal, V., Jain, S., … Purushottam, M. (2017). Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. Journal of Addictive Diseases, 36(1), 48–52. https://doi.org/10.1080/10550887.2016.1140434
Seshadri, M., Banerjee, D., Viswanath, B., Ramakrishnan, K., Purushottam, M., Venkatasubramanian, G., & Jain, S. (2017). Cellular models to study schizophrenia: A systematic review. Asian Journal of Psychiatry, 25, 46–53. https://doi.org/10.1016/j.ajp.2016.10.015
Velusamy, T., Panneerselvam, A. S., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S., … Kandasamy, M. (2017). Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity, 2017, 3279061. https://doi.org/10.1155/2017/3279061
Babu, R. A., Paul, P., Purushottam, M., Srinivas, D., Somanna, S., & Jain, S. (2016). Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms. Neurology India, 64(4), 663–670. https://doi.org/10.4103/0028-3886.185350

Contact Information:

Email: sjain.nimhans@gmail.com; sjain@nimhans.kar.nic.in

Phone: +91-9480829467 (M); +91-080-2699-5262 (O)

AddressDepartment of Psychiatry, National Institute of Mental Health & Neuro Sciences (NIMHANS), Hombegowda Nagar, Hosur Road, Bangalore, Karnataka, India, 560029