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\n\n\t\t5860128<\/span>\n\t\t<\/span>\n\t\tKBMQGC3H<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t2021<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tapa<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\ttitle<\/span>\n\t\t<\/span>\n <\/span>\n 18<\/span>\n\t\thttps:\/\/adbsnimhans.org\/wp-content\/plugins\/zotpress\/<\/span>\n\n\t\t
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%22%2C%22firstName%22%3A%22Sanjeev%22%2C%22lastName%22%3A%22Jain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ADBS%20Consortium%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Biju%22%2C%22lastName%22%3A%22Viswanath%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Neurocognitive%20deficits%20are%20considered%20an%20endophenotype%20for%20several%20psychiatric%20disorders%2C%20typically%20studied%20in%20unaffected%20first-degree%20relatives%20%28FDRs%29.%20Environmental%20factors%20such%20as%20adverse%20childhood%20experiences%20%28ACEs%29%20may%20also%20affect%20neurocognition.%20This%20study%20examines%20the%20effect%20of%20ACEs%20on%20neurocognitive%20performance%20in%20FDRs%20of%20patients%20with%20severe%20mental%20illness%20in%20order%20to%20determine%20whether%20familial%20risk%20has%20a%20moderating%20effect%20on%20the%20relationship%20between%20ACEs%20and%20neurocognition.Methods%20The%20sample%20consists%20of%20a%20total%20of%20512%20individuals%20composed%20of%20unaffected%20FDRs%20from%20multiplex%20families%20with%20severe%20mental%20illnesses%20%28schizophrenia%2C%20bipolar%20disorder%2C%20obsessive-compulsive%20disorder%20or%20alcohol%20use%20disorder%29%20and%20healthy%20controls%20%28with%20no%20familial%20risk%29.%20Neurocognitive%20tests%20included%20processing%20speed%20%28Color%20Trails%29%2C%20new%20learning%20%28Auditory%20Verbal%20Learning%20Test%29%2C%20working%20memory%20%28N-Back%29%2C%20and%20Theory%20of%20Mind%20%28SOCRATIS%29.%20ACEs%20were%20measured%20using%20the%20WHO%20ACE-International%20Questionnaire%20%28ACE-IQ%29.%20Regression%20models%20adjusted%20for%20age%2C%20gender%20and%20education%20were%20done%20to%20predict%20each%20neurocognitive%20domain%20by%20the%20effect%20of%20familial%20risk%2C%20ACE-IQ%20Total%20Score%20and%20the%20interaction%20%28familial%20risk%20x%20ACE-IQ%20Total%20score%29.Results%20When%20all%20FDRs%20were%20examined%20as%20a%20group%2C%20the%20main%20effect%20of%20familial%20risk%20predicted%20poor%20performance%20in%20all%20domains%20of%20neurocognition%20%28p%20%26lt%3B0.01%29%2C%20and%20the%20ACEs%20x%20familial%20risk%20interaction%20had%20a%20significant%20negative%20association%20with%20global%20neurocognition%2C%20processing%20speed%20%26amp%3B%20working%20memory.%20This%20interaction%20effect%20was%20driven%20predominantly%20by%20the%20familial%20risk%20of%20AUD.%20In%20FDRs%20of%20schizophrenia%20%26amp%3B%20bipolar%20disorder%2C%20only%20the%20main%20effects%20of%20familial%20risk%20were%20significant%20%28working%20memory%2C%20theory%20of%20mind%20%26amp%3B%20global%20neurocognition%29%2C%20with%20no%20impact%20of%20ACEs%20or%20its%20interaction%20in%20both%20these%20sub-groups.Conclusions%20The%20impact%20of%20childhood%20adversity%20on%20neurocognition%20is%20moderated%20by%20familial%20risk%20of%20psychiatric%20disorders.%20Genetic%20or%20familial%20vulnerability%20may%20play%20a%20greater%20role%20in%20disorders%20such%20as%20schizophrenia%20and%20bipolar%20disorder%2C%20while%20the%20interaction%20between%20ACEs%20and%20family%20history%20may%20be%20more%20relevant%20in%20the%20case%20of%20disorders%20with%20greater%20environmental%20risk%2C%20such%20as%20substance%20use.Competing%20Interest%20StatementThe%20authors%20have%20declared%20no%20competing%20interest.Clinical%20Protocols%20https%3A%5C%2F%5C%2Fbmcpsychiatry.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12888-018-1674-2%20Funding%20StatementThis%20research%20is%20funded%20by%20the%20Accelerator%20program%20for%20Discovery%20in%20Brain%20disorders%20using%20Stem%20cells%20%28ADBS%29%20%28jointly%20funded%20by%20the%20Department%20of%20Biotechnology%2C%20Government%20of%20India%2C%20and%20the%20Pratiksha%20trust%3B%20Grant%20BT%5C%2FPR17316%5C%2FMED%5C%2F31%5C%2F326%5C%2F2015%29.%20BV%20is%20funded%20by%20the%20Intermediate%20%28Clinical%20and%20Public%20Health%29%20Fellowship%20%28IA%5C%2FCPHI%5C%2F20%5C%2F1%5C%2F505266%29%20of%20the%20DBT%5C%2FWellcome%20Trust%20India%20Alliance.Author%20DeclarationsI%20confirm%20all%20relevant%20ethical%20guidelines%20have%20been%20followed%2C%20and%20any%20necessary%20IRB%20and%5C%2For%20ethics%20committee%20approvals%20have%20been%20obtained.YesThe%20details%20of%20the%20IRB%5C%2Foversight%20body%20that%20provided%20approval%20or%20exemption%20for%20the%20research%20described%20are%20given%20below%3AThe%20ethical%20approval%20for%20this%20work%20was%20given%20by%20the%20Institute%20Ethics%20Committee%2C%20National%20Institute%20of%20Mental%20Health%20and%20Neuro%20Sciences%20%28NIMHANS%29%2C%20Bangalore%2C%20Karnataka%2C%20IndiaI%20confirm%20that%20all%20necessary%20patient%5C%2Fparticipant%20consent%20has%20been%20obtained%20and%20the%20appropriate%20institutional%20forms%20have%20been%20archived%2C%20and%20that%20any%20patient%5C%2Fparticipant%5C%2Fsample%20identifiers%20included%20were%20not%20known%20to%20anyone%20%28e.g.%2C%20hospital%20staff%2C%20patients%20or%20participants%20themselves%29%20outside%20the%20research%20group%20so%20cannot%20be%20used%20to%20identify%20individuals.YesI%20understand%20that%20all%20clinical%20trials%20and%20any%20other%20prospective%20interventional%20studies%20must%20be%20registered%20with%20an%20ICMJE-approved%20registry%2C%20such%20as%20ClinicalTrials.gov.%20I%20confirm%20that%20any%20such%20study%20reported%20in%20the%20manuscript%20has%20been%20registered%20and%20the%20trial%20registration%20ID%20is%20provided%20%28note%3A%20if%20posting%20a%20prospective%20study%20registered%20retrospectively%2C%20please%20provide%20a%20statement%20in%20the%20trial%20ID%20field%20explaining%20why%20the%20study%20was%20not%20registered%20in%20advance%29.YesI%20have%20followed%20all%20appropriate%20research%20reporting%20guidelines%20and%20uploaded%20the%20relevant%20EQUATOR%20Network%20research%20reporting%20checklist%28s%29%20and%20other%20pertinent%20material%20as%20supplementary%20files%2C%20if%20applicable.YesRequests%20for%20the%20data%20related%20to%20this%20study%20may%20be%20addressed%20to%20the%20corresponding%20author%28s%29.%22%2C%22date%22%3A%222021-01-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1101%5C%2F2021.11.28.21266887%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fmedrxiv.org%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F11%5C%2F29%5C%2F2021.11.28.21266887.abstract%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KBMQGC3H%22%5D%2C%22dateModified%22%3A%222024-01-10T08%3A56%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22AR2U6WA5%22%2C%22library%22%3A%7B%22id%22%3A5860128%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lakkireddy%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLakkireddy%2C%20S.%20P.%2C%20Balachander%2C%20S.%2C%20Dayal%2C%20P.%2C%20Bhattacharya%2C%20M.%2C%20Joseph%2C%20M.%20S.%2C%20Kumar%2C%20P.%2C%20Kannampuzha%2C%20A.%20J.%2C%20Mallappagari%2C%20S.%2C%20Shruthi%2C%20S.%2C%20Chandy%2C%20A.%20A.%2C%20Kumaran%2C%20M.%2C%20Sheth%2C%20S.%2C%20Ramesh%2C%20V.%2C%20Puzhakkal%2C%20J.%20C.%2C%20Selvaraj%2C%20S.%20S.%2C%20Ithal%2C%20D.%2C%20Sreeraj%2C%20V.%20S.%2C%20Mahadevan%2C%20J.%2C%20Holla%2C%20B.%2C%20%5Cu2026%20Viswanath%2C%20B.%20%282021%29.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fmedrxiv.org%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F11%5C%2F29%5C%2F2021.11.28.21266887.abstract%26%23039%3B%26gt%3BNeurocognition%20and%20its%20association%20with%20adverse%20childhood%20experiences%20and%20familial%20risk%20of%20mental%20illness%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Bi%26gt%3BmedRxiv%26lt%3B%5C%2Fi%26gt%3B%2C%202021.11.28.21266887.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2021.11.28.21266887%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neurocognition%20and%20its%20association%20with%20adverse%20childhood%20experiences%20and%20familial%20risk%20of%20mental%20illness%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sai%20Priya%22%2C%22lastName%22%3A%22Lakkireddy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srinivas%22%2C%22lastName%22%3A%22Balachander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pavithra%22%2C%22lastName%22%3A%22Dayal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahashweta%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mino%20Susan%22%2C%22lastName%22%3A%22Joseph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pramod%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%20Jose%22%2C%22lastName%22%3A%22Kannampuzha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sreenivasulu%22%2C%22lastName%22%3A%22Mallappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suvarna%22%2C%22lastName%22%3A%22Shruthi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alen%20Alexander%22%2C%22lastName%22%3A%22Chandy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muthu%22%2C%22lastName%22%3A%22Kumaran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sweta%22%2C%22lastName%22%3A%22Sheth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vinutha%22%2C%22lastName%22%3A%22Ramesh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joan%20C%22%2C%22lastName%22%3A%22Puzhakkal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%20Sowmya%22%2C%22lastNa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Manjappa, P., Balachander, S., Naaz, S., Nadella, R. K., Shukla, T., Paul, P., Purushottam, M., Janardhan Reddy, Y. C., Jain, S., Viswanath, B., & Sud, R. (2021). Cell cycle abnormality is a cellular phenotype in OCD<\/a>. Asian Journal of Psychiatry<\/i>, 59<\/i>, 102637. https:\/\/doi.org\/10.1016\/j.ajp.2021.102637<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Parekh, P., Bhalerao, G. V., Rao, R., Sreeraj, V. S., Holla, B., Saini, J., Venkatasubramanian, G., John, J. P., Jain, S., & ADBS Consortium. (2021). Protocol for magnetic resonance imaging acquisition, quality assurance, and quality check for the Accelerator program for\u00a0Discovery in Brain disorders using Stem cells. International Journal of Methods in Psychiatric Research<\/i>, e1871. https:\/\/doi.org\/10.1002\/mpr.1871<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Nadella, R. K., Viswanath, B., & Jain, S. (2021). Climate change and urbanization: Historical trends and future impact on mental health in Bangalore<\/a>. Journal of Affective Disorders Reports<\/i>, 4<\/i>, 100119. https:\/\/doi.org\/10.1016\/j.jadr.2021.100119<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ithal, D., Sukumaran, S. K., Bhattacharjee, D., Vemula, A., Nadella, R., Mahadevan, J., Sud, R., Viswanath, B., Purushottam, M., & Jain, S. (2021). Exome hits demystified: the next frontier<\/a>. Asian Journal of Psychiatry<\/i>, 102640. https:\/\/doi.org\/10.1016\/j.ajp.2021.102640<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Bhattacharya, M., Balachander, S., Viswanath, B., & Reddy, Y. C. J. (2021). Comparison of neurocognitive performance in familial versus sporadic obsessive-compulsive disorder<\/a>. Journal of Obsessive-Compulsive and Related Disorders<\/i>, 30<\/i>, 100666. https:\/\/doi.org\/10.1016\/j.jocrd.2021.100666<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sreeraj, V. S., Puzhakkal, J. C., Holla, B., Nadella, R. K., Sheth, S., Balachander, S., Ithal, D., Ali, F., Viswanath, B., Muralidharan, K., Venkatasubramanian, G., John, J. P., Benegal, V., Murthy, P., Varghese, M., Reddy, Y. J., Jain, S., & Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) Consortium. (2021). Cross-diagnostic evaluation of minor physical anomalies in psychiatric disorders. Journal of Psychiatric Research<\/i>, 142<\/i>, 54\u201362. https:\/\/doi.org\/10.1016\/j.jpsychires.2021.07.028<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sakhardande, K. A., Reddi, V. S. K., Mishra, S., Navin, K., Ramu, A., Arunachal, G., Mangalore, S., Yadav, R., & Jain, S. (2021). Homozygous PLA2G6 (PARK 14) gene mutation associated neuropsychiatric phenotypes from southern India<\/a>. Parkinsonism & Related Disorders<\/i>, 90<\/i>, 49\u201351. https:\/\/doi.org\/10.1016\/j.parkreldis.2021.07.026<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Balachander, S., Meier, S., Matthiesen, M., Ali, F., Kannampuzha, A. J., Bhattacharya, M., Kumar Nadella, R., Sreeraj, V. S., Ithal, D., Holla, B., Narayanaswamy, J. C., Arumugham, S. S., Jain, S., Reddy, Y. J., & Viswanath, B. (2021). Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder? Frontiers in Psychiatry<\/i>, 12<\/i>, 651196. https:\/\/doi.org\/10.3389\/fpsyt.2021.651196<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mahadevan, J., Pathak, A. K., Vemula, A., Nadella, R. K., Viswanath, B., Jain, S., Rao, N. P., Narayanaswamy, J. C., Viswanath, B., Sivakumar, P. T., Kandasamy, A., Kesavan, M., Mehta, U. M., Venkatasubramanian, G., John, J. P., Purushottam, M., Mukherjee, O., Kannan, R., Mehta, B., \u2026 Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) Consortium. (2021). Analysis of whole exome sequencing in severe mental illness hints at selection of brain development and immune related genes<\/a>. Scientific Reports<\/i>, 11<\/i>(1), 21088. <\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lakkireddy, S. P., Balachander, S., Dayal, P., Bhattacharya, M., Joseph, M. S., Kumar, P., Kannampuzha, A. J., Mallappagari, S., Shruthi, S., Chandy, A. A., Kumaran, M., Sheth, S., Ramesh, V., Puzhakkal, J. C., Selvaraj, S. S., Ithal, D., Sreeraj, V. S., Mahadevan, J., Holla, B., \u2026 Viswanath, B. (2021). Neurocognition and its association with adverse childhood experiences and familial risk of mental illness<\/a>. medRxiv<\/i>, 2021.11.28.21266887. https:\/\/doi.org\/10.1101\/2021.11.28.21266887<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lakkireddy, S. P., Balachander, S., Dayal, P., Bhattacharya, M., Joseph, M. S., Kumar, P., Kannampuzha, A. J., Mallappagari, S., Shruthi, S., Chandy, A. A., Kumaran, M., Sheth, S., Ramesh, V., Puzhakkal, J. C., Selvaraj, S. S., Ithal, D., Sreeraj, V. S., Mahadevan, J., Holla, B., \u2026 Viswanath, B. (2021). Neurocognition and its association with adverse childhood experiences and familial risk of mental illness<\/a>. medRxiv<\/i>, 2021.11.28.21266887. https:\/\/doi.org\/10.1101\/2021.11.28.21266887<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mahadevan, J., Pathak, A. K., Vemula, A., Nadella, R. K., Viswanath, B., Jain, S., Rao, N. P., Narayanaswamy, J. C., Viswanath, B., Sivakumar, P. T., Kandasamy, A., Kesavan, M., Mehta, U. M., Venkatasubramanian, G., John, J. P., Purushottam, M., Mukherjee, O., Kannan, R., Mehta, B., \u2026 Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) Consortium. (2021). Analysis of whole exome sequencing in severe mental illness hints at selection of brain development and immune related genes<\/a>. Scientific Reports<\/i>, 11<\/i>(1), 21088. <\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sakhardande, K. A., Reddi, V. S. K., Mishra, S., Navin, K., Ramu, A., Arunachal, G., Mangalore, S., Yadav, R., & Jain, S. (2021). Homozygous PLA2G6 (PARK 14) gene mutation associated neuropsychiatric phenotypes from southern India<\/a>. Parkinsonism & Related Disorders<\/i>, 90<\/i>, 49\u201351. https:\/\/doi.org\/10.1016\/j.parkreldis.2021.07.026<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sreeraj, V. S., Puzhakkal, J. C., Holla, B., Nadella, R. K., Sheth, S., Balachander, S., Ithal, D., Ali, F., Viswanath, B., Muralidharan, K., Venkatasubramanian, G., John, J. P., Benegal, V., Murthy, P., Varghese, M., Reddy, Y. J., Jain, S., & Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) Consortium. (2021). Cross-diagnostic evaluation of minor physical anomalies in psychiatric disorders. Journal of Psychiatric Research<\/i>, 142<\/i>, 54\u201362. https:\/\/doi.org\/10.1016\/j.jpsychires.2021.07.028<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Bhattacharya, M., Balachander, S., Viswanath, B., & Reddy, Y. C. J. (2021). Comparison of neurocognitive performance in familial versus sporadic obsessive-compulsive disorder<\/a>. Journal of Obsessive-Compulsive and Related Disorders<\/i>, 30<\/i>, 100666. https:\/\/doi.org\/10.1016\/j.jocrd.2021.100666<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Balachander, S., Meier, S., Matthiesen, M., Ali, F., Kannampuzha, A. J., Bhattacharya, M., Kumar Nadella, R., Sreeraj, V. S., Ithal, D., Holla, B., Narayanaswamy, J. C., Arumugham, S. S., Jain, S., Reddy, Y. J., & Viswanath, B. (2021). Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder? Frontiers in Psychiatry<\/i>, 12<\/i>, 651196. https:\/\/doi.org\/10.3389\/fpsyt.2021.651196<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Parekh, P., Bhalerao, G. V., Rao, R., Sreeraj, V. S., Holla, B., Saini, J., Venkatasubramanian, G., John, J. P., Jain, S., & ADBS Consortium. (2021). Protocol for magnetic resonance imaging acquisition, quality assurance, and quality check for the Accelerator program for\u00a0Discovery in Brain disorders using Stem cells. International Journal of Methods in Psychiatric Research<\/i>, e1871. https:\/\/doi.org\/10.1002\/mpr.1871<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ithal, D., Sukumaran, S. K., Bhattacharjee, D., Vemula, A., Nadella, R., Mahadevan, J., Sud, R., Viswanath, B., Purushottam, M., & Jain, S. (2021). Exome hits demystified: the next frontier<\/a>. Asian Journal of Psychiatry<\/i>, 102640. https:\/\/doi.org\/10.1016\/j.ajp.2021.102640<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Manjappa, P., Balachander, S., Naaz, S., Nadella, R. K., Shukla, T., Paul, P., Purushottam, M., Janardhan Reddy, Y. C., Jain, S., Viswanath, B., & Sud, R. (2021). Cell cycle abnormality is a cellular phenotype in OCD<\/a>. Asian Journal of Psychiatry<\/i>, 59<\/i>, 102637. https:\/\/doi.org\/10.1016\/j.ajp.2021.102637<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mahadevan, J., Sud, R., Nadella, R. K., Vani, P., Subramaniam, A. G., Paul, P., Ganapathy, A., Mannan, A. U., Chandru, V., Viswanath, B., Purushottam, M., & Jain, S. (2021). Targeted Sequencing Detects Variants That May Contribute to the Risk of Neuropsychiatric Disorders<\/a>. Indian Journal of Psychological Medicine<\/i>, 025371762199367. https:\/\/doi.org\/10.1177\/0253717621993672<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Nadella, R. K., Viswanath, B., & Jain, S. (2021). Climate change and urbanization: Historical trends and future impact on mental health in Bangalore<\/a>. Journal of Affective Disorders Reports<\/i>, 4<\/i>, 100119. https:\/\/doi.org\/10.1016\/j.jadr.2021.100119<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sreeraj, V. S., Holla, B., Ithal, D., Nadella, R. K., Mahadevan, J., Balachander, S., Ali, F., Sheth, S., Narayanaswamy, J. C., Venkatasubramanian, G., John, J. P., Varghese, M., Benegal, V., Jain, S., Reddy, Y. J., ADBS Consortium, & Viswanath, B. (2021). Psychiatric symptoms and syndromes transcending diagnostic boundaries in Indian multiplex families: The cohort of ADBS study. Psychiatry Research<\/i>, 296<\/i>, 113647. https:\/\/doi.org\/10.1016\/j.psychres.2020.113647<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Bhalerao, G. V., Parekh, P., Saini, J., Venkatasubramanian, G., John, J. P., & ADBS consortium. (2021). Systematic evaluation of the impact of defacing on quality and volumetric assessments on T1-weighted MR-images. Journal of Neuroradiology = Journal De Neuroradiologie<\/i>. https:\/\/doi.org\/10.1016\/j.neurad.2021.03.001<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Soundararajan, S., Agrawal, A., Purushottam, M., Anand, S. D., Shankarappa, B., Sharma, P., Jain, S., & Murthy, P. (2021). Changes in DNA methylation persist over time in males with severe alcohol use disorder-A longitudinal follow-up study. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics<\/i>. https:\/\/doi.org\/10.1002\/ajmg.b.32833<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ali, F., Sreeraj, V. S., Nadella, R. K., Holla, B., Mahadevan, J., Ithal, D., Balachander, S., Viswanath, B., Venkatasubramanian, G., John, J. P., Reddy, Y. C. J., & Jain, S. (2021). Estimating the familial risk of psychiatric illnesses: A review of family history scores. Asian Journal of Psychiatry<\/i>, 56<\/i>, 102551. https:\/\/doi.org\/10.1016\/j.ajp.2021.102551<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Paul, P., Nadella, R. K., Viswanath, B., Reddy, Y. C. J., Jain, S., & Purushottam, M. (2021). Does CACNA1C rs1006737 genotype play a role in lithium treatment response in bipolar disorder patients? Asian Journal of Psychiatry<\/i>, 56<\/i>, 102525. https:\/\/doi.org\/10.1016\/j.ajp.2020.102525<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\n\t\t5860128<\/span>\n\t\t<\/span>\n\t\tKBMQGC3H<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t2020<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tapa<\/span>\n\t\t50<\/span>\n\t\tdefault<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\ttitle<\/span>\n\t\t<\/span>\n <\/span>\n 18<\/span>\n\t\thttps:\/\/adbsnimhans.org\/wp-content\/plugins\/zotpress\/<\/span>\n\n\t\t
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Shukla, T., Nadella, R. K., Taj M J, R. J., Ganesh, S., Nestadt, G., Purushottam, M., Jain, S., Reddy, Y. C. J., & Viswanath, B. (2020). Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. Experimental and Clinical Psychopharmacology<\/i>, 28<\/i>(6), 617\u2013621. https:\/\/doi.org\/10.1037\/pha0000348<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ratna, N., Kamble, N. L., Venkatesh, S. D., Purushottam, M., Pal, P. K., & Jain, S. (2020). Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington\u2019s disease. BMC Neurology<\/i>, 20<\/i>(1), 87. https:\/\/doi.org\/10.1186\/s12883-020-01671-x<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Vani, P., Nadella, R. K., Viswanath, B., & Jain, S. (2020). Mutism as a component of obsessive-compulsive symptoms in patients with schizophrenia: A report of two cases. Asian Journal of Psychiatry<\/i>, 54<\/i>, 102337. https:\/\/doi.org\/10.1016\/j.ajp.2020.102337<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Vani, P., Nadella, R. K., Viswanath, B., & Jain, S. (2020). Mutism as a component of obsessive-compulsive symptoms in patients with schizophrenia: A report of two cases. Asian Journal of Psychiatry<\/i>, 54<\/i>, 102337. https:\/\/doi.org\/10.1016\/j.ajp.2020.102337<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Paul, P., Iyer, S., Nadella, R. K., Nayak, R., Chellappa, A. S., Ambardar, S., Sud, R., Sukumaran, S. K., Purushottam, M., Jain, S., ADBS Consortium (ADBS: The Accelerator program for Discovery in Brain disorders using Stem cells), & Viswanath, B. (2020). Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines. Scientific Reports<\/i>, 10<\/i>(1), 7428. https:\/\/doi.org\/10.1038\/s41598-020-64202-1<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ratna, N., Kamble, N. L., Venkatesh, S. D., Purushottam, M., Pal, P. K., & Jain, S. (2020). Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington\u2019s disease. BMC Neurology<\/i>, 20<\/i>(1), 87. https:\/\/doi.org\/10.1186\/s12883-020-01671-x<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Shukla, T., Nadella, R. K., Taj M J, R. J., Ganesh, S., Nestadt, G., Purushottam, M., Jain, S., Reddy, Y. C. J., & Viswanath, B. (2020). Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. Experimental and Clinical Psychopharmacology<\/i>, 28<\/i>(6), 617\u2013621. https:\/\/doi.org\/10.1037\/pha0000348<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Naaz, S., Balachander, S., Srinivasa Murthy, N., Ms, B., Sud, R., Saha, P., Narayanaswamy, J. C., Reddy Yc, J., Jain, S., Purushottam, M., & Viswanath, B. (2020). Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder. Experimental and Clinical Psychopharmacology<\/i>. https:\/\/doi.org\/10.1037\/pha0000422<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Someshwar, A., Holla, B., Pansari Agarwal, P., Thomas, A., Jose, A., Joseph, B., Raju, B., Karle, H., Muthukumaran, M., Kodancha, P. G., Kumar, P., Reddy, P. V., Kumar Nadella, R., Naik, S. T., Mitra, S., Mallappagiri, S., Sreeraj, V. S., Balachander, S., Ganesh, S., \u2026 ADBS Consortium. (2020). Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses. The Australian and New Zealand Journal of Psychiatry<\/i>, 54<\/i>(11), 1086\u20131094. https:\/\/doi.org\/10.1177\/0004867420931157<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sadh, K., Mehta, U. M., Muralidharan, K., Shankar, N. S., & Jain, S. (2020). Understanding the role of language in patients with psychosis and hearing impairment, experiencing auditory verbal hallucinations. Schizophrenia Research<\/i>, 222<\/i>, 487\u2013488. https:\/\/doi.org\/10.1016\/j.schres.2020.05.063<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Bhattacharya, M., Balachander, S., Viswanath, B., Reddy, Y. C. J., & Jain, S. (2020). Comparison of Neuropsychological Performance in Familial and Sporadic Obsessive-Compulsive Disorder<\/a>. Biological Psychiatry<\/i>, 87<\/i>(9), S263\u2013S264. https:\/\/doi.org\/10.1016\/j.biopsych.2020.02.681<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mahadevan, J., Sud, R., Nadella, R. K., P, V., Subramaniam, A. G., Paul, P., G, A., Mannan, A. U., Chandru, V., Purushottam, M., Viswanath, B., & Jain, S. (2020). An audit and insights from clinical exome sequencing in psychiatry: genotype-phenotype correlation<\/a><\/i> [Preprint]. Open Science Framework. https:\/\/doi.org\/10.31219\/osf.io\/5fu6t<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Anjanappa, R. M., Nayak, S., Moily, N. S., Manduva, V., Nadella, R. K., Viswanath, B., Reddy, Y. C. J., Jain, S., & Anand, A. (2020). A linkage and exome study implicates rare variants of KANK4 and CAP2 in bipolar disorder in a multiplex family<\/a>. Bipolar Disorders<\/i>, 22<\/i>(1), 70\u201378. https:\/\/doi.org\/10.1111\/bdi.12815<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Holla, B., Dayal, P., Das, A., Bhattacharya, M., Manjula, V., Ithal, D., Dalachander, S., Mahadevan, J., Nadella, R. K., Sreeraj, V. S., Benegal, V., Reddy, J. Y. C., Mehta, U. M., Viswanath, B., & ADBS Consortium. (2020). Transdiagnostic neurocognitive endophenotypes in major psychiatric illness<\/a><\/i> [Preprint]. medRxiv. https:\/\/doi.org\/10.1101\/2020.02.14.20022863<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Ashok, A., Naaz, S., Kota, L. N., Sen, S., Purushottam, M., Faruq, M., Kumari, R., Yadav, V., Kannan, R., Jain, S., Panicker, M. M., & Viswanath, B. (2019). Does retinoic acid reverse cell cycle dysregulation in Alzheimer\u2019s disease lymphocytes? Asian Journal of Psychiatry<\/i>, 39<\/i>, 174\u2013177. https:\/\/doi.org\/10.1016\/j.ajp.2018.08.010<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ganesh, S., Ahmed P, H., Nadella, R. K., More, R. P., Seshadri, M., Viswanath, B., Rao, M., Jain, S., ADBS Consortium, & Mukherjee, O. (2019). Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes. Psychiatry and Clinical Neurosciences<\/i>, 73<\/i>(1), 11\u201319. https:\/\/doi.org\/10.1111\/pcn.12788<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Timothy, A., Benegal, V., Shankarappa, B., Saxena, S., Jain, S., & Purushottam, M. (2019). Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics. Progress in Neuro-Psychopharmacology & Biological Psychiatry<\/i>, 94<\/i>, 109649. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109649<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Anjanappa, R. M., Jain, S., Wali, G. M., & Purushottam, M. (2019). Genetic analysis of a family from India with Machado-Joseph disease. Neurology India<\/i>, 67<\/i>(2), 582\u2013588. https:\/\/doi.org\/10.4103\/0028-3886.258030<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Najar, A. H., Sneha, K. M., Ashok, A., Babu, S., Subramaniam, A. G., Kannan, R., Viswanath, B., Purushottam, M., Varghese, M., Parvez, S., Panicker, M. M., Mukherjee, O., & Jain, S. (2019). Derivation of iPSC lines from two patients with familial Alzheimer\u2019s disease from India. Stem Cell Research<\/i>, 34<\/i>, 101370. https:\/\/doi.org\/10.1016\/j.scr.2018.101370<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Nadella, R. K., Chellappa, A., Subramaniam, A. G., More, R. P., Shetty, S., Prakash, S., Ratna, N., Vandana, V. P., Purushottam, M., Saini, J., Viswanath, B., Bindu, P. S., Nagappa, M., Mehta, B., Jain, S., & Kannan, R. (2019). Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance. Human Genomics<\/i>, 13<\/i>(1), 53. https:\/\/doi.org\/10.1186\/s40246-019-0236-0<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Nadella, R. K., Chellappa, A., Subramaniam, A. G., More, R. P., Shetty, S., Prakash, S., Ratna, N., Vandana, V. P., Purushottam, M., Saini, J., Viswanath, B., Bindu, P. S., Nagappa, M., Mehta, B., Jain, S., & Kannan, R. (2019). Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance. Human Genomics<\/i>, 13<\/i>(1), 53. https:\/\/doi.org\/10.1186\/s40246-019-0236-0<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ganesh, S., Ahmed P, H., Nadella, R. K., More, R. P., Seshadri, M., Viswanath, B., Rao, M., Jain, S., ADBS Consortium, & Mukherjee, O. (2019). Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes. Psychiatry and Clinical Neurosciences<\/i>, 73<\/i>(1), 11\u201319. https:\/\/doi.org\/10.1111\/pcn.12788<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ashok, A., Naaz, S., Kota, L. N., Sen, S., Purushottam, M., Faruq, M., Kumari, R., Yadav, V., Kannan, R., Jain, S., Panicker, M. M., & Viswanath, B. (2019). Does retinoic acid reverse cell cycle dysregulation in Alzheimer\u2019s disease lymphocytes? Asian Journal of Psychiatry<\/i>, 39<\/i>, 174\u2013177. https:\/\/doi.org\/10.1016\/j.ajp.2018.08.010<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Najar, A. H., Sneha, K. M., Ashok, A., Babu, S., Subramaniam, A. G., Kannan, R., Viswanath, B., Purushottam, M., Varghese, M., Parvez, S., Panicker, M. M., Mukherjee, O., & Jain, S. (2019). Derivation of iPSC lines from two patients with familial Alzheimer\u2019s disease from India. Stem Cell Research<\/i>, 34<\/i>, 101370. https:\/\/doi.org\/10.1016\/j.scr.2018.101370<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Anjanappa, R. M., Jain, S., Wali, G. M., & Purushottam, M. (2019). Genetic analysis of a family from India with Machado-Joseph disease. Neurology India<\/i>, 67<\/i>(2), 582\u2013588. https:\/\/doi.org\/10.4103\/0028-3886.258030<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Timothy, A., Benegal, V., Shankarappa, B., Saxena, S., Jain, S., & Purushottam, M. (2019). Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics. Progress in Neuro-Psychopharmacology & Biological Psychiatry<\/i>, 94<\/i>, 109649. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109649<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Paul, P., Dahale, A., Kishore, B., Chand, P., Benegal, V., Jain, S., Murthy, P., & Purushottam, M. (2017). Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. Journal of Addictive Diseases<\/i>, 36<\/i>(1), 48\u201352. https:\/\/doi.org\/10.1080\/10550887.2016.1140434<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Velusamy, T., Panneerselvam, A. S., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S., Essa, M. M., Guillemin, G. J., & Kandasamy, M. (2017). Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington\u2019s Disease. Oxidative Medicine and Cellular Longevity<\/i>, 2017<\/i>, 3279061. https:\/\/doi.org\/10.1155\/2017\/3279061<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Thippeswamy, H., Paul, P., Purushottam, M., Philip, M., Jain, S., & Chandra, P. S. (2017). Estrogen pathway related genes and their association with risk of postpartum psychosis: A case control study. Asian Journal of Psychiatry<\/i>, 26<\/i>, 82\u201385. https:\/\/doi.org\/10.1016\/j.ajp.2017.01.014<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Shankarappa, B. M., Kota, L. N., Purushottam, M., Nagpal, K., Mukherjee, O., Viswanath, B., Varghese, M., Bharath, S., & Jain, S. (2017). Effect of CLU and PICALM polymorphisms on AD risk: A study from south India. Asian Journal of Psychiatry<\/i>, 27<\/i>, 7\u201311. https:\/\/doi.org\/10.1016\/j.ajp.2016.12.017<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Seshadri, M., Banerjee, D., Viswanath, B., Ramakrishnan, K., Purushottam, M., Venkatasubramanian, G., & Jain, S. (2017). Cellular models to study schizophrenia: A systematic review. Asian Journal of Psychiatry<\/i>, 25<\/i>, 46\u201353. https:\/\/doi.org\/10.1016\/j.ajp.2016.10.015<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Velusamy, T., Panneerselvam, A. S., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S., Essa, M. M., Guillemin, G. J., & Kandasamy, M. (2017). Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington\u2019s Disease. Oxidative Medicine and Cellular Longevity<\/i>, 2017<\/i>, 3279061. https:\/\/doi.org\/10.1155\/2017\/3279061<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Paul, P., Dahale, A., Kishore, B., Chand, P., Benegal, V., Jain, S., Murthy, P., & Purushottam, M. (2017). Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. Journal of Addictive Diseases<\/i>, 36<\/i>(1), 48\u201352. https:\/\/doi.org\/10.1080\/10550887.2016.1140434<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Thippeswamy, H., Paul, P., Purushottam, M., Philip, M., Jain, S., & Chandra, P. S. (2017). Estrogen pathway related genes and their association with risk of postpartum psychosis: A case control study. Asian Journal of Psychiatry<\/i>, 26<\/i>, 82\u201385. https:\/\/doi.org\/10.1016\/j.ajp.2017.01.014<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Seshadri, M., Banerjee, D., Viswanath, B., Ramakrishnan, K., Purushottam, M., Venkatasubramanian, G., & Jain, S. (2017). Cellular models to study schizophrenia: A systematic review. Asian Journal of Psychiatry<\/i>, 25<\/i>, 46\u201353. https:\/\/doi.org\/10.1016\/j.ajp.2016.10.015<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Shankarappa, B. M., Kota, L. N., Purushottam, M., Nagpal, K., Mukherjee, O., Viswanath, B., Varghese, M., Bharath, S., & Jain, S. (2017). Effect of CLU and PICALM polymorphisms on AD risk: A study from south India. Asian Journal of Psychiatry<\/i>, 27<\/i>, 7\u201311. https:\/\/doi.org\/10.1016\/j.ajp.2016.12.017<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Babu, R. A., Paul, P., Purushottam, M., Srinivas, D., Somanna, S., & Jain, S. (2016). Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms. Neurology India<\/i>, 64<\/i>(4), 663\u2013670. https:\/\/doi.org\/10.4103\/0028-3886.185350<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Babu, R. A., Paul, P., Purushottam, M., Srinivas, D., Somanna, S., & Jain, S. (2016). Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms. Neurology India<\/i>, 64<\/i>(4), 663\u2013670. https:\/\/doi.org\/10.4103\/0028-3886.185350<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Viswanath, B., Jose, S. P., Squassina, A., Thirthalli, J., Purushottam, M., Mukherjee, O., Vladimirov, V., Patrinos, G. P., Del Zompo, M., & Jain, S. (2015). Cellular models to study bipolar disorder: A systematic review. Journal of Affective Disorders<\/i>, 184<\/i>, 36\u201350. https:\/\/doi.org\/10.1016\/j.jad.2015.05.037<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lenka, A., Kamble, N. L., Sowmya, V., Jhunjhunwala, K., Yadav, R., Netravathi, M., Kandasamy, M., Moily, N. S., Purushottam, M., Jain, S., & Pal, P. K. (2015). Determinants of Onset of Huntington\u2019s Disease with Behavioral Symptoms: Insight from 92 Patients. Journal of Huntington\u2019s Disease<\/i>, 4<\/i>(4), 319\u2013324. https:\/\/doi.org\/10.3233\/JHD-150166<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Kota, L. N., Bharath, S., Purushottam, M., Moily, N. S., Sivakumar, P. T., Varghese, M., Pal, P. K., & Jain, S. (2015). Reduced telomere length in neurodegenerative disorders may suggest shared biology. The Journal of Neuropsychiatry and Clinical Neurosciences<\/i>, 27<\/i>(2), e92-96. https:\/\/doi.org\/10.1176\/appi.neuropsych.13100240<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Vijayakumari, A. A., John, J. P., Halahalli, H. N., Paul, P., Thirunavukkarasu, P., Purushottam, M., & Jain, S. (2015). Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects. Clinical Psychopharmacology and Neuroscience: The Official Scientific Journal of the Korean College of Neuropsychopharmacology<\/i>, 13<\/i>(1), 68\u201382. https:\/\/doi.org\/10.9758\/cpn.2015.13.1.68<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lenka, A., Kamble, N. L., Sowmya, V., Jhunjhunwala, K., Yadav, R., Netravathi, M., Kandasamy, M., Moily, N. S., Purushottam, M., Jain, S., & Pal, P. K. (2015). Determinants of Onset of Huntington\u2019s Disease with Behavioral Symptoms: Insight from 92 Patients. Journal of Huntington\u2019s Disease<\/i>, 4<\/i>(4), 319\u2013324. https:\/\/doi.org\/10.3233\/JHD-150166<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Kota, L. N., Purushottam, M., Moily, N. S., & Jain, S. (2015). Shortened telomere in unremitted schizophrenia. Psychiatry and Clinical Neurosciences<\/i>, 69<\/i>(5), 292\u2013297. https:\/\/doi.org\/10.1111\/pcn.12260<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Vijayakumari, A. A., John, J. P., Halahalli, H. N., Paul, P., Thirunavukkarasu, P., Purushottam, M., & Jain, S. (2015). Erratum: Figure Correction. Clinical Psychopharmacology and Neuroscience: The Official Scientific Journal of the Korean College of Neuropsychopharmacology<\/i>, 13<\/i>(2), 224\u2013225. https:\/\/doi.org\/10.9758\/cpn.2015.13.2.224<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Viswanath, B., Jose, S. P., Squassina, A., Thirthalli, J., Purushottam, M., Mukherjee, O., Vladimirov, V., Patrinos, G. P., Del Zompo, M., & Jain, S. (2015). Cellular models to study bipolar disorder: A systematic review. Journal of Affective Disorders<\/i>, 184<\/i>, 36\u201350. https:\/\/doi.org\/10.1016\/j.jad.2015.05.037<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Kota, L. N., Bharath, S., Purushottam, M., Moily, N. S., Sivakumar, P. T., Varghese, M., Pal, P. K., & Jain, S. (2015). Reduced telomere length in neurodegenerative disorders may suggest shared biology. The Journal of Neuropsychiatry and Clinical Neurosciences<\/i>, 27<\/i>(2), e92-96. https:\/\/doi.org\/10.1176\/appi.neuropsych.13100240<\/a><\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Posters presented at the World Congress of Psychiatric Genetics, 2019 in Los Angeles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Other Poster Presentations:<\/span><\/b><\/p><\/h3>\n

          Directly related to the project<\/span><\/b><\/p>\n

1.   <\/span><\/span><\/span>Search for Trans-Diagnostic Neuropsychological Endophenotypes In Severe Mental Illness \u2013 Preliminary Data From A Family Based Study. Dayal Pavithra et al., 11th international congress of the international neuropsychiatric association, India, February 2018 (Received Best Poster Award)<\/span><\/p>\n

2.    <\/span><\/span><\/span>Mitochondrial Dysfunction in Bipolar Disorders: Is there a difference between responders and non-responders? Shruti Iyer et al. 2018. Stem Cell Biology & Disease Models conference, NCBS, Feb 2018.<\/span><\/p>\n

3.    <\/span><\/span><\/span>Functional characterization of a novel GAP43 Variant using patient derived stem cells. Anand G Subramaniam et al. 2018. NCBS stem cell conference.<\/span><\/p>\n

4.    <\/span><\/span><\/span>Integrating global and phosphoproteomics networks identifies modifying pathways of APOE in AD. Manasa KP et al. 2018. NCBS stem cell conference.<\/span><\/p>\n

5.    <\/span><\/span><\/span>Does having a family member with Severe Mental Disorder affect the duration of untreated illness in subsequently affected family members? Preeti Pansari Agarwal et al, 2018. ANCIPS, Ranchi<\/span><\/p>\n

6.   <\/span><\/span><\/span>Search for Trans-diagnostic Neurobiological Endophenotype for severe Mental Illness\u2013 Analytical Challenges. Nirmala M and Jija Syamala James & ADBS consortium. inStem Annual Review at Institute for Stem Cell Biology and Regenerative Medicine in February 2018.<\/span><\/p>\n

7.     <\/span><\/span><\/span>The impact of Polarity of the First mood episode on 5 year course of Bipolar Disorder (BD): A retrospective review. Preeti Agarwal et al 2018. K C Dube Poster Session Awarded<\/span><\/p>\n

8.     <\/span><\/span><\/span>Outline of accelerator program for discovery in brain disorders using stem cells: clinical and endophenotype measures. ADBS NIMHANS clinical team. NCBS annual talks 2016 poster no 81.<\/span><\/p>\n

9.    <\/span><\/span><\/span>The impact of duration of untreated illness of first severe mental disorder affected family member on subsequently affected family members. Muthukumaran M et.al<\/span><\/a>., 2018, Bipolar CME poster presented under Award category<\/span><\/p>\n

10.  <\/span><\/span><\/span>Does life events predict work and social adjustment in people with Severe Mental illness: a Preliminary study. Birudu Raju et al., 2018, Bipolar CME poster presented under Award category.<\/span><\/p>\n

11.  <\/span><\/span><\/span>Cell cycle analysis in obsessive compulsive disorder.  Safoora Naaz et al, 2nd Symposium on OCD and Related Disorders: An update on research & treatment practices. OCD Clinic, Department of Psychiatry, NIMHANS, Bangalore, on 28th & 29th October 2017.<\/span><\/p>\n

12.  <\/span><\/span><\/span>Mitochondrial Dysfunction and Cell Death in Bipolar Disorder, Pradip Paul et al. NIMHANS-SBDI World Bipolar Day 2018 joint CME, Bangalore,2018 (Received Best Poster Award)<\/span><\/p>\n

13.  <\/span><\/span><\/span>Life events as a predictor of work and social adjustment in persons with severe mental illness \u2013 a preliminary study. M Muthukumaran et al., 36th Annual Conference of Indian Society for Professional Social Workers March 2018, Pondicherry.<\/span><\/p>\n

14.  <\/span><\/span><\/span>Influence of APOE genotype in NSC stress response derived from Alzheimer\u2019s patients. Sneha KM et al. Instem annual review of research, Bangalore, Feb 26 – 28th 2018.<\/span><\/p>\n

15.  <\/span><\/span><\/span>Genetic correlates of lithium sensitivity in a deeply characterized BPAD cohort.  Vidya V et al. inStem annual review of research, Bangalore, Feb 26 – 28th 2018.<\/span><\/p>\n

16.  <\/span><\/span><\/span>Mapping mitochondrial dysfunction in Alzheimer\u2019s disease patient derived neural stem cells. Sneha KM et al., Stem cell biology and disease models symposium, Bangalore, February 2-3, 2018.<\/span><\/p>\n

17.  <\/span><\/span><\/span>Allele dependent role of ApoE modifier in Alzheimer\u2019s disease biology. Manasa et al., Stem cell biology and disease models symposium, Bangalore, February 2-3, 2018.<\/span><\/p>\n

18.  <\/span><\/span><\/span>Functional characterization of a novel GAP43 variant using patient derived neural stem cells. Anand et al., Stem cell biology and disease models symposium, Bangalore, February 2-3, 2018.<\/span><\/p>\n

19.  <\/span><\/span><\/span>Growth stunting and severe mental illness and of bird, brain and voice. Mustafa Ali et al,.  NCBS annual talks, Bangalore, January 2018.<\/span><\/p>\n

20.  <\/span><\/span><\/span>Association Study of BDNF Polymorphism With Bipolar Disorder Patients In The Southern Indian Population. Pradip Paul et al., International Society for Bipolar Disorder, Washington DC, USA, 2017. (Travel award).<\/span><\/p>\n

21.  <\/span><\/span><\/span>BDNF and COMT polymorphism with Lithium response in Bipolar Disorder: A pharmacogenetics study. Pradip Paul et al., World Federation of the Societies of Biological Psychiatry (WFSBP) conference, Copenhagen, Denmark, 2017.(Young Investigator Travel award)<\/span><\/p>\n

22.  <\/span><\/span><\/span>Mood stabilisers improve cell viability and mitochondrial membrane potential in vitro. Pradip Paul et al., 25th World Congress of Psychiatry Genetics, Orlando, Florida,USA, October,2017. (Young Investigator Travel award)<\/span><\/p>\n

23.  <\/span><\/span><\/span>Mitochondrial dysfunction in Alzheimer\u2019s disease. Somadatta Sen et al., 25th World Congress of Psychiatry Genetics, Orlando, Florida,USA, 2017. (Early Career Investigator award)<\/span><\/p>\n

24.  <\/span><\/span><\/span>Effects of Lithium\/ Valproate on Cell Death and Mitochondrial Membrane Potential in Bipolar Disorder Using Flow cytometry. Pradip Paul et al., Society for Mitochondrial Research and Medicine conference, New Delhi, 2017.<\/span><\/p>\n

25.  <\/span><\/span><\/span>Association study of BDNF and COMT polymorphism with bipolar disorder patients in the southern Indian population. Pradip Paul et al., Second Global Conference of Biological Psychiatry, Bangalore, 2016. (Received II best poster)<\/span><\/p>\n

26.  <\/span><\/span><\/span>Modelling neuropsychiatric disorders using patient derived cell lines \u2013 bridging the genotype phenotype gap. Shruthi Iyer et al., NCBS annual talks, Bangalore, 2016.<\/span><\/p>\n

27.  <\/span><\/span><\/span>Suicidality and Lithium treatment response in bipolar disorder. BS Raghuraman et al., 2nd World congress of Early career psychiatrists, Athens, Greece, 2016.<\/span><\/p>\n

28.  <\/span><\/span><\/span>Neuropsychological Functioning in Individuals with Shared Vulnerability for Bipolar Disorder and Obsessive-Compulsive Disorder. Mahashweta Bhattacharya et al. NIMHANS-SBDI World Bipolar Day CME, Bangalore, 2019.<\/span><\/p>\n

29.  <\/span><\/span><\/span>Cross cutting affective symptoms in \u201cunaffected\u201d individuals of multiplex families. Anand Jose et al. NIMHANS-SBDI World Bipolar Day CME, Bangalore, 2019.<\/span><\/p>\n

30.  <\/span><\/span><\/span>Mutation burden in lipid metabolism genes. R Sharma et al. Alzheimer’s Association Internal Conference, Satellite meet at Bangalore, December 2018.<\/span><\/p>\n

31.  <\/span><\/span><\/span>Migration: a tool for analysing the cellular phenotype for Neural stem cell lines derived from patients diagnosed for bipolar disorder. Salil k Sukumaran et al. NIMHANS-SBDI World Bipolar Day CME, Bangalore, 2019 (Awarded Best Poster).<\/span><\/p>\n

32.  <\/span><\/span><\/span>Does perceived social support impact the quality of life in persons with BPAD under remission? Birudu Raju et. al. NIMHANS-SBDI World Bipolar Day CME, Bangalore, 2019<\/span><\/p>\n

33.  <\/span><\/span><\/span>A genomic approach to understand the cellular basis of Severe Mental Illness. Ravi K Nadella et al. Instem Annual Review 2019, Bangalore.<\/span><\/p>\n

34.  <\/span><\/span><\/span>Is ICM based approach a necessity for multiplex families? – Looking in the mirror of Bipolar Disorder. Muthukumaran M et.al. NIMHANS-SBDI World Bipolar Day CME, Bangalore, 2019<\/span><\/p>\n

35.  <\/span><\/span><\/span>Molecular Mechanisms of Lithium Response in Bipolar disorder: A Cellular Model System Based Study. Pradip Paul et al. 26th World Congress of Psychiatric Genetics, Glasgow, Scotland, 2018 (Early Career Investigator Award)<\/span><\/p>\n

36. <\/span><\/span><\/span>Differences in neuro-hemodynamic responses between serotonin-reuptake inhibitor responders versus non-responders: A resting state fMRI study. Balachander S et al, 14th World Congress of Biological Psychiatry, Vancouver, Canada (Young Investigator Award), 2019<\/span><\/p>\n

37. Impact of Family History Density and Adverse Childhood Experiences on Age of Onset of Psychiatric Illnesses. World Congress of Psychiatric Genetics, Los Angeles, USA, 2019<\/span><\/p>\n

38. Familiality of Symptom Dimensions in Obsessive-Compulsive Disorder. <\/span>World Congress of Psychiatric Genetics, Los Angeles, USA, 2019<\/span><\/p>\n

39. A genomic approach to understand the cellular basis of severe mental illnesses. <\/span>World Congress of Psychiatric Genetics, Los Angeles, USA, 2019<\/span><\/p>\n

40. Transdiagnostic neurocognitive endophenotypes in severe mental illnesses. <\/span>World Congress of Psychiatric Genetics, Los Angeles, USA, 2019<\/span><\/p>\n

41. Comparison of neuropsychological performance in familial and sporadic obsessive-compulsive disorder. Society of Biological Psychiatry, New York 2020 (Virtual Conference)<\/span><\/p>\n

42. Whole exome sequencing reveals rare variants in FTD-genes in early onset severe psychosis. Alzheimer’s Association International Conference 2020<\/span><\/p>\n

43. Constraint-based modeling of astrocyte metabolism in neuropsychiatric disorders: RBCDSAI Summit at IIT, Madras 2020<\/span><\/p>\n

44. Reconstruction of astrocyte-specific metabolic models to identify the mechanisms of action of lithium. Cold Spring Harbor Laboratory Virtual Meeting 2020<\/span><\/p>\n

\n<\/p>

 <\/span><\/p>\n

  Indirectly related to project <\/span><\/b><\/p>\n

1.    <\/span><\/span><\/span>NR1D1 gene expression and Lithium treatment response in Bipolar Disorder. Ravi Nadella et al. NIMHANS-SBDI World Bipolar Day 2018 joint CME, Bangalore, 2018.<\/span><\/p>\n

2.    <\/span><\/span><\/span>COMT Polymorphism and Bipolar Disorder in Indian Population. Ravi Kumar Nadella et al. International Society for Bipolar Disorder, Washington DC, 2017. (Travel award)<\/span><\/p>\n

3.    <\/span><\/span><\/span>Pharmacogenetic association between glutamatergic genes and SRI treatment response in obsessive compulsive disorder. Shukla T et al. 2nd Symposium on OCD and related disorders, Bangalore, October 28-29, 2017.<\/span><\/p>\n

4.  <\/span><\/span><\/span>GSK-3B 50 T\/C Polymorphism and associated clinical parameters in patients with bipolar disorder. Bharathram Sathur Raghuraman et al. 25th World Congress of Psychiatry Genetics, Orlando, Florida,USA, October,2017. (Travel award).<\/span><\/p>\n

5.    <\/span><\/span><\/span>Molecular genetic study of serotonin 2A receptor gene locus in Bipolar Disorder. Pradip Paul et al. Indian Society of Human Genetics conference, Bangalore, 2017.<\/span><\/p>\n

6.    <\/span><\/span><\/span>GSK-3B 50 T\/C Polymorphism and Lithium Maintenance Treatment in Bipolar Disorder. Bharathram Sathur Raghuraman et. al. 24th World Congress of Psychiatry Genetics. Jerusalem, Israel, October,2016.(Travel award)<\/span><\/p>\n

7.    <\/span><\/span><\/span>Prevalence of Tobacco Use Among the Middle School Students. Pramod Kumar et. al. 37th annual National Conference of Indian Society of Professional Social Work (ISPSW), Department of Psychiatric Social Work, NIMHANS \u2013 Bengaluru, January 2019<\/span><\/p>\n

 <\/span><\/b><\/p>\n

Conference Presentations<\/span><\/b><\/p>\n

1.    <\/span><\/span><\/span>Life events as a predictor of work and social adjustment in persons with severe mental illness- a preliminary study\u201d. Muthukumaran M and Birudu Raju. 2018. Annual National conference of ISPSW (Indian Society for Professional Social Workers), Pondicherry Central University, Pondicherry.<\/span><\/p>\n

2.    <\/span><\/span><\/span>Cellular models in psychiatric disorders. Biju Viswanath, 2018.  11th International Congress of the International Neuropsychiatric Association (TSS-NIMHANS conclave), Bangalore, February 15-17, 2018.<\/span><\/p>\n

3.    <\/span><\/span><\/span>Genetics and cellular models of OCD. Biju Viswanath, 2017. 2nd Symposium on OCD and related disorders, Bangalore, October 28-29, 2017.<\/span><\/p>\n

4.    <\/span><\/span><\/span>Cellular models: Newer insights. Biju Viswanath, 2016. 2nd Global conference of biological psychiatry, Bangalore, August 12-14, 2016.<\/span><\/p>\n

5.    <\/span><\/span><\/span>Cellular models in psychiatry. Biju Viswanath, 2016. 68th Annual National Conference of Indian Psychiatric Society, Bhopal, January 21-24, 2016.<\/span><\/p>\n

6.  <\/span><\/span><\/span>Role of Psychiatric Social Workers in Family Therapy. Keynote lecture- Birudu Raju, 2019. National Seminar-“Growing Distance between families due to modern technology”, Feb 2019. Department of Social Work, St. Joseph’s College of Arts and Science, Cuddalore, Tamilnadu.<\/span><\/p>\n

7.   <\/span><\/span><\/span>Symposium presentation – 71st Annual National Conference of Indian Psychiatric Society (ANCIPS-2019) from 31st January to 03rd February, 2019 at Lucknow, UP. Discovering the biology of neuropsychiatric syndromes: Generating potentials from the Accelerator program for discovery in brain Dr. Sreeraj VS, Dr. Bharath Holla, Dr. Biju Viswanath, Dr. Sanjeev Jain.<\/span><\/p>\n

8.    <\/span><\/span><\/span>Using \u2018omics\u2019 to decipher the enigmas of psychopharmacology.  Dr. Sanjeev Jain. 7th International Symposium on Current Trends in Drug Discovery Research, February 2019, CDRI, Lucknow.<\/span><\/p>\n

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